Measurement of overall motion, as well as specific subtypes of activity such as circadian rhythms and particular aspects of locomotion, can be used as an integrated readout for tracking disease progression. Vium's platform enables motion tracking of subjects non-invasively and is used as a measure to track disease progression and treatment in a variety of animal models.
Measuring changes in breathing rate can lead to the early detection of disease and is key in evaluating the safety profile of novel therapeutics. A range of conditions including exercise, stress, lung disorders, cardiovascular disease, metabolic acidosis, drug overdose, and central nervous system abnormalities can all manifest in detectable alterations in breathing rate.
The Vium Arthritis Index enables researchers to evaluate the efficacy and safety of therapeutic interventions in rodent models of RA through near realtime measurements and data analysis. Our use of physiological measurements combined with advanced analytics provides a highly sensitive readout of arthritis induction, as well as clinically relevant measures of therapeutic response.
We hypothesize that continuous monitoring of behavioral and physiological parameters will provide clinically relevant data to assess disease in induction rodent models, including the Con A- induced mouse model of liver disease. The objective of this study was to evaluate behavioral and physiological characteristics of Con A-induced mice using different doses of Con A.
We hypothesize that continuous monitoring of behavioral and physiological parameters will provide additional meaningful data to assess disease and efficacy in genetic rodent models of disease, including SLE. To address this hypothesis, the objectives of this study were: 1) To investigate behavioral and physiological characteristics of MRL/lpr mice using a low-touch, continuous monitoring platform, and 2) To evaluate and compare the effects of standard of care (SOC) compounds on conventional disease measures as well as behavioral and physiological phenotypes in MRL/lpr mice.