Mouse Model of Liver Toxicity
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We hypothesize that continuous monitoring of behavioral and physiological parameters will provide clinically relevant data to assess disease in induction rodent models, including the Con A- induced mouse model of liver disease. The objective of this study was to evaluate behavioral and physiological characteristics of Con A-induced mice using different doses of Con A.
MRL/lpr Model of Systemic Lupus Erythematosus
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We hypothesize that continuous monitoring of behavioral and physiological parameters will provide additional meaningful data to assess disease and efficacy in genetic rodent models of disease, including SLE. To address this hypothesis, the objectives of this study were: 1) To investigate behavioral and physiological characteristics of MRL/lpr mice using a low-touch, continuous monitoring platform, and 2) To evaluate and compare the effects of standard of care (SOC) compounds on conventional disease measures as well as behavioral and physiological phenotypes in MRL/lpr mice.
Paraquat Model of Lung Injury
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Current challenges provide opportunities to develop low- touch, automated, in-life methods to assess pulmonary function and lung edema in rodents. We hypothesize that Vium’s automated Digital Biomarkers, specifically Breathing Rate, will provide physiologically relevant data to assess respiratory disease progression in a PQ-induced rat model of lung injury.
Phenotying Mouse Models
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The rapid growth of systems biology approaches in preclinical research, such as whole-genome sequencing and genome editing, has contributed to the need for high-throughput and reproducible phenotypic screening of genetically engineered animals. The relationship between genotype and phenotype is complex: targeted genes of interest interact with background genes and unknown mutations, as well as epigenetic and environmental factors, to exert specific or collective effects on health and behavior.
Bleomycin Model of Pulmonary Fibrosis
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Here we demonstrate how Vium’s platform can be used to monitor respiratory disease progression in a bleomycin mouse model of ideopathic pulmonary fibrosis (IPF). Vium’s automated Breathing Rate showed strong and distinct changes as early as three days post-induction until close to study end. Although further investigation is required to assess the underlying disease mechanisms, initial evidence suggests reduced breathing rates early in disease may reflect the acute inflammatory phase and elevated breathing rates later in disease may reflect the chronic fibrotic phase of disease, generally characterizing this model.
Pseudomonas aeruginosa Model of Lung Infection
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Here we demonstrate how Vium’s platform can be used to monitor respiratory disease progression in a Pseudomonas aeruginosa (PA01)-induced mouse model of lung infection. Vium’s Digital Biomarkers, specifically automated Breathing Rate, showed changes as early as eight hours post-infection, and these changes persisted until close to study end. The advantage of using a continuous monitoring platform to evaluate breathing rates in the home cage is the ability to observe animals in their natural behavioral states across longer periods of time, which may lead to more sensitive and consistent data collection.
Featured: Gene Therapy Efficacy Assessment in Batten Mice Using the Vium Digital Vivarium
Developed in conjunction with the University of Pennsylvania Perelman School of Medicine.
CLN2 disease, a form of Batten disease, is a neurodegenerative lysosomal storage disorder caused by mutations in the gene encoding the soluble enzyme tripeptidyl- peptidase-1 (TPP1). This model recapitulates most features of the human disease such as shortened lifespan, seizures, or abnormal gait. Monitoring of the neurobehavioral function in this model is challenging, however, as they are prone to noise- or stress-induced fatal seizures when handled. Real time non-invasive continuous monitoring using smart cages (Vium, Inc.) allows sensitive and non-biased recording of disease phenotype and treatment-related rescue in a seizure-prone mouse model, while limiting handling-related deaths.
Presented at AALAS National Meeting 2018
Presented at AALAS National Meeting 2018
Presented at Immunology 2018
Presented at Immunology 2016
Presented at the AALAS NCB Annual Symposium
In Conjunction with UPenn
Presented at Neuroscience 2016
Presented at World Preclinical Congress 2017