Case Studies

Scientific Posters

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Featured: Gene Therapy Efficacy Assessment in Batten Mice Using the Vium Digital Vivarium


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Developed in conjunction with the University of Pennsylvania Perelman School of Medicine. 

CLN2 disease, a form of Batten disease, is a neurodegenerative lysosomal storage disorder caused by mutations in the gene encoding the soluble enzyme tripeptidyl- peptidase-1 (TPP1). This model recapitulates most features of the human disease such as shortened lifespan, seizures, or abnormal gait. Monitoring of the neurobehavioral function in this model is challenging, however, as they are prone to noise- or stress-induced fatal seizures when handled. Real time non-invasive continuous monitoring using smart cages (Vium, Inc.) allows sensitive and non-biased recording of disease phenotype and treatment-related rescue in a seizure-prone mouse model, while limiting handling-related deaths.

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MS Drug Efficacy Assessment (PDF) 

Presented at Neuroscience 2016

Automated Disease Assessment in Graft versus Host Disease (PDF) 

Presented at World Preclinical Congress 2017

Brochures & Tech Notes

Brochures

Tech Notes

Digital Vivarium Overview

Overview of the Digital Vivarium System

Vium Arthritis Index™

Automated Index to Track Disease Progression

Vium Smart Housing

An Introduction to Vium Smart Housing

Running Wheel Metric

Continuously Monitor Animal Wheel Running Activity

Vium Research Suite

Vium's Online Portal for Viewing, Analyzing, and Managing Studies

Breathing Rate Metric

Breathing Rate Changes Monitored Non-Invasively 24/7

Discovery Lab

Providing Discovery Services and Model Development

Motion Metric

Continuously Monitor Motion In Real Time